No peroxisome is an island — Peroxisome contact sites

Mind the Organelle Gap - Peroxisome Contact Sites in Disease.

The eukaryotic cell is organized as a complex grid system where membrane-bound cellular compartments, organelles, must be localized to the right place at the right time. One way to facilitate correct organelle localization and organelle cooperation is through membrane contact sites, areas of close proximity between two organelles that are bridged by protein/lipid complexes. It is now clear that...

An ER-peroxisome tether exerts peroxisome population control in yeast.

Eukaryotic cells compartmentalize biochemical reactions into membrane-enclosed organelles that must be faithfully propagated from one cell generation to the next. Transport and retention processes balance the partitioning of organelles between mother and daughter cells. Here we report the identification of an ER-peroxisome tether that links peroxisomes to the ER and ensures peroxisome populatio...

No man is an island.

No doctor is an island

No doctor is an island " expand the knowledge base of PH and the complexities of diagnosis and management of this group of patients " ; and lobbying power, " to create a force that will have levels of influence on many facets of PH management in Australia and New Zealand. " [3] (See the PHSANZ abstracts published in this issue of Pulmonary Circulation). they were joined by still more people in ...

No man is an island…

As much of my work is collaborative, I am very aware of the virtues and difficulties of collaboration in the modern scientific world. Most collaborations are short term; perhaps one scientist has an assay, the other a reagent, and an obvious quick gain will result from joining forces. But greater (though often less concrete) benefits come from longer term collaborations. Your collaborator may b...